Zix-MR 8mg Tablet (Aceclofenac 100mg/Thiocolchicoside 8mg)

INTRODUCTION

ZIX MR 8MG is a combination of Aceclofenac and Thiocolchicoside, which belongs to the group of medicines called Non-Steroidal Anti-inflammatory Drugs and Muscle relaxants respectively. It is used in adults to treat painful inflammatory conditions associated with muscle spasms.

ZIX MR 8MG can also be used to treat pain associated with musculoskeletal (bone) disorders such as osteoarthritis, rheumatoid arthritis (inflammation of joints) or ankylosing spondylitis (back pain caused due to inflammation of bones in the spine).

Aceclofenac is a non-steroidal anti-inflammatory drug. It acts by blocking the production of certain chemicals that causes pain and inflammation in the body. Thiocolchicoside is a muscle relaxant. It relaxes the muscles by blocking the action of certain chemical messengers (GABA) in the brain that causes muscle spasm. As a result, ZIX MR 8MG relieves painful muscle spasms associated with inflammatory disease conditions.

Before taking ZIX MR 8MG, inform your doctor if you have any problems in your liver, liver, kidney, heart, or stomach. You much also inform your doctor if you have diabetes, high blood cholesterol or fits.

Do not take ZIX MR 8MG if you have asthma or varicella infection. Consult your doctor before taking ZIX MR 8MG if you are pregnant, think you may be pregnant or breastfeeding.

Take ZIX MR 8MG only as advised by your doctor. Do not take ZIX MR 8MG longer than recommended by your doctor as it may cause serious side effects. Avoid smoking and consumption of alcohol while undergoing therapy with ZIX MR 8MG to achieve better results.

The most common side effects of taking ZIX MR 8MG are dizziness, drowsiness, nausea, and stomach pain. Consult your doctor if any of these side effect worsens.

USES OF ZIX MR 8MG

It is used in adults to treat:

• Painful muscle spasms
• Pain associated with musculoskeletal disorders (such as osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis)

HOW ZIX MR 8MG WORKS

ZIX MR 8MG is a muscle relaxant with anti-inflammatory and analgesic properties. It effectively reduces pain caused due to muscle spasms and inflammatory bone disorders, where aceclofenac acts by blocking the release of certain chemicals (prostaglandins) that causes pain and inflammation in the body and thiocolchicoside acts by blocking the effects of certain chemical messengers (GABA) in the brain that causes painful muscle spasms. Collectively, ZIX MR 8MG relieves painful muscle spasms associated with inflammatory disease conditions.

DIRECTIONS FOR USE

Take ZIX MR 8MG as directed by your physician. Swallow the medicine with a glass of water and do not crush or chew the medicine. ZIX MR 8MG can be taken 1 hour before or 2 hours after meals. Your doctor will decide the correct dose for you depending upon your health condition.

SIDE EFFECTS OF ZIX MR 8MG

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Take ZIX MR 8MG with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Diarrhoea:

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Indigestion:

Eat when you are hungry. Try to eat smaller meals more often than usual. Snack only when you’re hungry. Always try to have a nutritious snack that is high in calories and protein, such as dried fruit and nuts.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking ZIX MR 8MG, inform your doctor if you are taking any of the following medicines such as:

• Medicines used to treat nausea or vomiting (Ex. metoclopramide or domperidone)
• Medicines used for blood thinning (Ex. warfarin)
• Medicines used to reduce blood pressure (Ex. enalapril, olmesartan, losartan)
• Cardiac glycosides used to treat heart failure (Ex. digoxin, digitoxin)
• Medicines used to treat bacterial infection (such as ciprofloxacin, ofloxacin, levofloxacin or moxifloxacin)
• Medicines used to treat HIV infections (such as zidovudine)
• Medicines used to reduce blood sugar levels (such as glibenclamide, glycoside, and tolbutamide)
• Medicines used for pain relief (such as aspirin or ibuprofen)
• Oral corticosteroids (used to treat pain and inflammation) Ex. dexamethasone
• Proton-pump inhibitors (used to reduce stomach acid production) Ex. omeprazole
• SSRI (used to treat depression) Ex. citalopram, fluoxetine, sertraline
• Misoprostol (used to treat or prevent stomach ulcers)
• Immunosuppressants (used to suppress immune function) Ex. cyclosporin, tacrolimus
• Colestyramine (a medicine used to control blood cholesterol levels)
• Diuretics (used to increase urine output) Ex. furosemide
• Lithium (a medicine used to treat mental illness)
• Methotrexate (a medicine used to treat auto-immune diseases or cancer)
• Mifepristone (birth control pill)

Overdosage:

If you or anyone else accidentally took more ZIX MR 8MG, contact your doctor immediately. Symptoms of overdosage might include nausea, vomiting, upper stomach pain, headache, gastrointestinal bleeding, diarrhoea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, and convulsions.