Endace 160 mg Tablet (Megestrol)

Description

The primary ingredient of Endace-160 Tablet is available as an oral suspension and oral tablets. The oral suspension form of this medicine is used for the treatment of loss of appetite and weight loss in patients with acquired immunodeficiency syndrome (AIDS). The oral tablets are used in the palliative treatment of advanced breast cancer and advanced endometrial cancer (cancer that arose from the lining of the uterus). This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Endace-160 Tablet
Sleeplessness
Rash
Sweating
Diarrhea
Indigestion
Mood swings
Weight gain
Nausea
Vomiting
Increase in blood pressure
Increased thirst

Uses of Endace-160 Tablet

What is it prescribed for?
Anorexia Nervosa
The oral suspension form of this medicine is used to treat anorexia nervosa, an eating disorder characterized by low body weight and a fear of gaining weight.
Cachexia
The oral suspension form of this medicine is used to treat extreme weight loss and muscle wasting caused due to severe chronic illness like acquired immunodeficiency syndrome (AIDS).
Breast cancer
The oral tablet form of this medicine is used in the palliative treatment of advanced breast cancer.
Endometrial cancer
The oral tablet form of this medicine is used in the palliative treatment of endometrial cancer, a type of cancer that arose from the lining of the uterus.
Unexplained Weight Loss
The oral suspension form of this medicine is used in the treatment of weight loss in patients with acquired immunodeficiency syndrome (AIDS)

Dosage

Endace 40 mg
Endace 160 mg

When not to use?

Allergy
This medicine is not recommended for use in patients with a known allergy to megestrol acetate or any other inactive ingredients present along with it.

Warnings

Warnings for special population
Pregnancy
This medicine is recommended for use in pregnancy only if the need is clinically established. Consult your doctor before using this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition
General warnings
Vaginal bleeding
Use of this medicine may increase the risk of vaginal bleeding in women. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Report any unusual symptoms to the doctor on priority.
Diabetes
This medicine should be used with caution in patients with diabetes due to the increased risk of alterations in blood glucose levels. Regular monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Prophylactic therapy for weight loss
This medicine is not recommended as prophylactic therapy for weight loss and also as a diagnostic test for pregnancy.
Adrenal insufficiency
This medicine may increase the risk of adrenal insufficiency in some patients on therapy or being withdrawn from long-term therapy with this medicine.
Liver impairment
This medicine should be used with caution in patients with liver diseases due to the increased risk of worsening of the patient’s condition. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Use in children
This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.
Fluid retention
This medicine should be used with caution in patients having a fluid retention disorder or are exposed to the risk factors due to the increased risk of worsening of the patient’s condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Retinal thrombosis
Use of this medicine can cause a disturbance in vision and other problems in the eyes. It should be used with caution in patients suffering from a pre-existing eye disease. Use of this medicine should be stopped immediately if a visual disturbance is observed.

Dosage

Missed Dose
Take/consume the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Thalidomide
Darunavir
Efavirenz
Glimepiride
Cyclosporine
Dofetilide
Disease interactions
Thromboembolism
This medicine is not recommended for use in patients with thromboembolism (a clotting disorder in which the formed clot moves from one place and lodges in another place) since it may worsen the patient’s condition. Replacement with a suitable alternative may be required based on the clinical condition.
Diabetes Mellitus
This medicine should be used with caution in patients with diabetes mellitus since it may cause glucose intolerance. Regular monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take/consume this medicine with or without food. Do not take/consume in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking/consuming the medicine before completion of the course/without consulting your doctor.