INTRODUCTION
ZOFER MD 4MG contains Ondansetron which belongs to a group of medicines called anti-emetics, which help to stop feeling or being sick. It is indicated to prevent and treat nausea and vomiting induced by cytotoxic therapy and radiotherapy and post-operative nausea and vomiting. This medicine works by blocking the action of serotonin levels in the brain which causes nausea and vomiting during chemotherapy or any other surgery.
Cytotoxic chemotherapy triggers the release of serotonin from the enterochromaffin cells of the small intestine. The released serotonins stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex. Ondansetron is a selective 5-HT3 receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
Always take ZOFER MD 4MG exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. Your doctor will decide the right dose depends on your child’s age and body weight. The common side effects are headache, constipation and dizziness.
USES OF ZOFER MD 4MG
- Cancer chemotherapy-induced nausea and vomiting
- Postoperative nausea and/or vomiting
HOW ZOFER MD 4MG WORKS
ZOFER MD 4MG is a selective 5-HT3-receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
DIRECTIONS FOR USE
Always take ZOFER MD 4MG exactly as your doctor has told you. Swallow as a whole, do not crush or chew. It can be taken with or without food.
SIDE EFFECTS OF ZOFER MD 4MG
SERIOUS
- Sudden wheezing and chest pain or tightness
- Swelling of the eyelids, lips, mouth tongue or throat
- Difficulty breathing
- Skin rash
- Fits (seizures)
- Chest pain
- Temporary loss of vision
COMMON
- Headache
- Sensation of flushing and warmth
- Constipation
RARE
- Dizziness or light headedness
- Blurred vision
- Disturbance in heart rhythm
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and drink plenty of fluids.
Constipation:
Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
WARNING & PRECAUTIONS
PREGNANCY
ZOFER MD 4MG is not recommended in the first trimester of pregnancy unless necessary. Consult your doctor for advice.
BREASTFEEDING
ZOFER MD 4MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
This medicine is unlikely to affect your ability to drive or operate machinery.
LIVER
ZOFER MD 4MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Ondansetron.
HEART DISEASE
ZOFER MD 4MG should be used with caution in patients suffering from uneven heart beat or any other active heart diseases. Consult your doctor for advice.
OTHERS
Inform your doctor if you have or had,
- Blockage in your gut or suffer from severe constipation
- Surgery to the adenoids or tonsils
- Problems with the levels of salts in blood like potassium and magnesium
INTERACTIONS
Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,
- Apomorphine (used to treat Parkinson’s Disease)
- Phenytoin, carbamazepine (used to treat epilepsy)
- Rifampicin, erythromycin (an antibiotic)
- Tramadol (used to treat pain)
- Medicines used to treat heart problems such as abnormal heart beats (anti-arrhythmics) and high blood pressure (betablockers)
- Anthracyclines
- Ketoconazole (used to treat fungal infection)
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