INTRODUCTION
LIPICURE CV 10/75MG is a combination of Atorvastatin and Clopidogrel which belongs to the group of medicines called HMG-CoA reductase inhibitors and Antiplatelet medicines respectively. LIPICURE CV 10/75MG is used to reduce elevated cholesterol and triglyceride levels in patients when a low-fat diet and lifestyle changes alone have failed. It can also be used to reduce the risk of heart problems such as myocardial infarction (heart attack), stroke (reduced blood supply to brain leading to brain death), angina (chest pain), heart failure or revascularization procedures in adult patients with or without a clinically evident chronic heart disease.
Atorvastatin reduces the production of bad cholesterol and clopidogrel blocks the aggregation of platelets in the blood vessels, leading to prevention of heart problems. Along with the treatment, the patient should follow an appropriate lipid-lowering diet as advised by their doctor to enhance recovery.
LIPICURE CV 10/75MG is not suitable for use in children aged below 18 years. Before using LIPICURE CV 10/75MG, inform your doctor if you have any liver or kidney disease. Patients with an active liver disease should discontinue the use of LIPICURE CV 10/75MG as it may cause serious side effects in them. LIPICURE CV 10/75MG is not recommended for use in pregnant or breast-feeding women and in patients with bleeding disorders.
Avoid consumption of grapefruit juice or alcohol while taking LIPICURE CV 10/75MG as it may lead to unwanted interactions. Consult your doctor for advice before taking. The most common side effects of taking LIPICURE CV 10/75MG are muscle pain, joint pain, diarrhea, nausea, headache, or stomach pain. Consult your doctor if any of the symptoms worsen.
USES OF LIPICURE CV 10/75MG
- To reduce elevated cholesterol and triglyceride levels in patients when a low-fat diet and lifestyle changes alone have failed
- To reduce the risk of heart problems such as myocardial infarction (MI), stroke, angina, heart failure or revascularization procedures in adult patients with or without a clinically evident chronic heart disease
HOW LIPICURE CV 10/75MG WORKS
LIPICURE CV 10/75MG reduces elevated cholesterol and risk of heart disease, where atorvastatin acts by inhibiting the action of an enzyme called HMG-CoA reductase, which is required to catalyze the formation of cholesterol and clopidogrel acts by inhibiting platelet aggregation, which is believed to be an important factor resulting in heart problems (such as MI, stroke, cardiac failure, or angina).
DIRECTIONS FOR USE
Take LIPICURE CV 10/75MG as advised by your physician. Swallow LIPICURE CV 10/75MG with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
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SIDE EFFECTS OF LIPICURE CV 10/75MG
COMMON
- Diarrhoea
- Stomach pain
- Indigestion or heartburn
- Inflammation of nasal passages, pain in throat, nosebleed
- Allergic reactions
- Headache
- Nausea, constipation, flatulence, indigestion
- Joint pain, muscle and back pain
UNCOMMON
- Loss of appetite
- Weight gain
- Decrease in blood sugar levels (in diabetic patients)
- Nightmares, insomnia
- Dizziness, numbness or tingling sensation in finger or toes
- Reduction of sensation to pain or touch, change in sense of taste
- Loss of memory, blurred vision
- Ringing in the ears or head
- Vomiting, belching, upper and lower abdominal pain
- Inflammation of pancreas (leading to stomach pain)
- Inflammation of liver
- Stomach ulcer
- Skin rash and itching
- Hair loss
- Neck pain, muscle tiredness
- Feeling unwell, tiredness, weakness, or chest pain
- Swelling especially in the ankles (oedema), raised temperature
RARE
- Visual disturbance
- Unexpected bleeding or bruising
- Cholestasis (yellowing of the skin and whites of the eyes)
- Tendon injury
- Vertigo, enlarged breasts in males
Stop taking LIPICURE 10/75MG and contact your doctor immediately if you experience the following side effects:
- Severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat which can lead to difficulty in breathing or swallowing)
- Rhabdomyolysis (abnormal muscle breakdown causing muscle weakness, pain, tenderness, red-brown discoloration of urine, weakness and raised body temperature)
- Lupus-like disease syndrome (such as joint disorders, rash and altered count of blood cells)
- Unexpected or unusual bleeding or bruising, hematoma
- Severe skin reactions (such as peeling and swelling of the skin, blistering of skin around mouth, eyes, genitals, and fever. Skin rash with red raised lumps on palms of hands or sole of the feet)
- Signs of liver problems such as yellowing of the skin and/or the eyes (jaundice), whether associated with bleeding which appears under the skin as red pinpoint dots
- Signs of infection or extreme tiredness (due to decrease of some blood cells)
HOW TO MANAGE SIDE EFFECTS
Stomach pain:
Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Avoid eating oily, spicy or fried foods. If the symptom does not improve, contact your doctor.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. Consult your doctor if the symptom did not improve.
Constipation:
Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.
WARNING & PRECAUTIONS
PREGNANCY
LIPICURE CV 10/75MG is not recommended for use in pregnant women. Consult your doctor before taking LIPICURE 10/75MG if you are pregnant or planning to get pregnant.
BREASTFEEDING
LIPICURECV 10/75MG is not recommended for use in breast-feeding women. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected after taking LIPICURE CV 10/75MG.
ALCOHOL
Avoid consumption of alcohol while taking LIPICURE CV 10/75MG.
KIDNEY
LIPICURE CV 10/75MG should be used with caution in patients with kidney disease. Consult your doctor before taking LIPICURE 10/75MG.
LIVER
LIPICURE CV 10/75MG is not recommended for use in patients with active liver disease including unexplained persistent elevations in hepatic transaminase levels. Consult your doctor before taking LIPICURE CV 10/75MG.
ALLERGY
Do not take LIPICURE CV 10/75MG if you are allergic to Atorvastatin or Clopidogrel.
LUNGS
LIPICURE CV 10/75MG should be used with caution in patients with severe respiratory failure. Consult your doctor before taking LIPICURE CV 10/75MG.
OTHERS
LIPICURE CV 10/75MG is not recommended for use if you have:
- Bleeding disorders (such as bleeding in gastro-intestinal tract due to stomach ulcer or bleeding within the brain)
Before taking LIPICURE CV 10/75MG, inform your physician if you have:
- Hypothyroidism, diabetes
- Repeated or unexplained muscle aches or pains
- Personal history or family history of muscle problems
- Previous muscular problems during treatment with other lipid-lowering medicines (such as rosuvastatin or fenofibrate)
- Blood disorder that makes you prone to internal bleeding (bleeding inside any tissues, organs, or joints of your body)
- Recent serious injury
- Recent surgery (including dental surgery)
- Any planned surgeries
- Ischemic stroke which occurred within the last seven days.
- Past medical history of non-traumatic brain hemorrhage
- Allergy or reaction to any medicine used to treat your disease.
Use in pediatrics:
LIPICURE CV 10/75MG is not recommended for use in children and adolescents (below 18 years) due to lack of safety and effectiveness. Consult child’s doctor for advice.
Use in geriatrics:
LIPICURE CV 10/75MG should be used with caution in elderly patients (65 years of age or above). During prolonged treatment with LIPICURE CV 10/75MG your doctor will monitor you regularly. Consult your doctor before taking LIPICURE CV 10/75MG.
INTERACTIONS
A. Drug-Drug interactions:
Before taking LIPICURE CV 10/75MG inform to your doctor, if you are taking any of these medicines:
- Other medicines used to control high blood cholesterol levels (Ex. cholestyramine, colestipol, gemfibrozil, ezetimibe)
- Ticlopidine (used to prevent stroke)
- Medicines used to treat depression (Ex. fluoxetine, fluvoxamine, citalopram, sertraline, venlafaxine, duloxetine, desvenlafaxine)
- Niacin (a vitamin supplement)
- Cyclosporin (an immunosuppressant used to prevent graft rejection)
- Telithromycin, clarithromycin, fusidic acid (used to treat bacterial infections)
- HIV protease inhibitors (used to treat HIV infections) such as ritonavir or lopinavir
- Itraconazole (used to treat fungal infections)
- Proton pump inhibitors (used to treat stomach ulcers) Ex. omeprazole and esomeprazole
- Repaglinide (used to treat diabetes)
- Paclitaxel (used to treat some forms of cancer)
- Rifampin (used to treat tuberculosis)
- Digoxin (used to treat abnormal heart rate)
- Oral contraceptives (Ex. norethindrone and ethinyl estradiol) (used to prevent pregnancy)
- Colchicine (used to treat gout)
- Non-steroidal anti-inflammatory agents (NSAIDs) (used to treat pain) Ex. aspirin
- Heparin and warfarin (used to reduce blood clotting)
- St. john’s wort (used to mental illness)
B. Drug-Food interaction:
While taking LIPICURE CV 10/75MG, avoid taking large quantities (not more than one or two small glasses) of grapefruit juice as it can alter the effects of this medicine resulting in undesired therapeutic outcome.
Overdosage:
If you or anyone else take too much of LIPICURE CV 10/75MG, contact your doctor immediately or go to a hospital straight away because of increased risk of bleeding.
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