Divalpro XR 250 Tablet (Divalproex)

Divalpro XR 250 Tablet

Divalpro 250 MG Tablet XR is an anticonvulsant medication that is used for the treatment of certain types of epilepsies, a brain disorder characterized by uncontrolled jerking movements and loss of consciousness. It is also used for the treatment of mania and as prophylaxis in migraine headaches. Take this medicine at the same time regularly.

Substitutes

List of substitutes for Divalpro 250 MG Tablet XR
Depakote 250 MG Tablet XR
Sanofi India Ltd.
Dilpra 250 MG Tablet XR
Emcure Pharmaceuticals Ltd.
Rex-Xr 250 MG Tablet XR
Abbott India Ltd.
Trend 250 MG Tablet XR
Torrent Pharmaceuticals Ltd.

Side effects

Major & minor side effects for Divalpro 250 MG Tablet XR
Diarrhea
Confusion
Headache
Muscle pain
Unusual tiredness and weakness
Sleepiness
Anxiety
Blurred vision
Yellow colored eyes or skin
Weight gain
Acid or sour stomach
Skin rash
Irregular menstrual periods
Ear pain

Uses of Divalpro 250 MG Tablet XR

What is it prescribed for?
Epilepsy
This medicine is used in the treatment of epilepsy which is a brain disorder that causes repeated seizures. Uncontrolled jerking movements and loss of consciousness are some of the symptoms of epilepsy.
Mania
This medicine is used in the treatment of mania which is a mental disorder characterized by hyperactivity and racing thoughts.
Migraine Prophylaxis
This medicine is used as prophylaxis in migraine headaches characterized by a severe headache, eye pain, nausea, and vomiting.

Dosage

Divalpro XR 250 Tablet
Divalpro XR 500 Tablet

When not to use?

Allergy
This medicine is not recommended for use in patients with a known allergy to Divalproex, or any other inactive ingredients present along with the formulation.
Active and/or severe liver disease
This medicine is not recommended for use in patients with active and/or severe liver diseases.
Urea cycle disorders
This medicine is not recommended for use in patients with urea cycle disorders (high ammonium levels in the blood) or family history of urea cycle disorder.
Mitochondrial disorders
This medicine is not recommended for use in patients and children who are suspected to have the mitochondrial disorder (POLG e.g Alpers-Huttenlocher Syndrome).
Porphyria
This medicine is not recommended for use in patients suffering from porphyria, a disorder where there is an over-accumulation of porphyrin in the body.

Warnings

Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings
Pancreatitis
This medicine may cause severe pancreatitis which is a serious life-threatening reaction in some patients. Discontinue the medicine if pancreatitis is detected. Report any signs and symptoms such as nausea, vomiting, or acute abdominal pain, etc. to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.
Bleeding disorder
Use with caution in patients with bleeding disorders as it may cause Thrombocytopenia. Make necessary dosage adjustments or discontinue the medicine if this condition is identified.
Suicidal ideation
This medicine may increase the risk of suicidal thoughts. Appropriate dose adjustments should be done in patients with depression or suicidal tendencies.
Systemic lupus erythematosus
This medicine should be used with caution in patients with Systemic lupus erythematosus due to the risk of worsening of the patient’s condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Use in elderly population
This medicine should be used with caution in elderly patients due to the risk of dizziness. The safety and efficacy of this medicine in the prophylaxis of migraines is not established.
Impaired kidney function
This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient’s condition. Close monitoring of kidney function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Weight gain
Therapy with this medicine may cause weight gain in some patients.
Driving and operating machinery
This medicine may cause symptoms such as weakness, drowsiness, sleepiness, dizziness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery if you experience any of these symptoms.

Dosage

Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, difficulty in concentration, drowsiness, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine
Lamotrigine
Metoclopramide
Warfarin
Ethinyl Estradiol
Meropenem
Disease interactions
Depression
This medicine should be used with caution in patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition. Do not stop the use of any medicine without consulting your doctor.
Liver Disease
This medicine should be used with extreme caution in patients with liver diseases due to the risk of worsening of the condition. Liver function tests are to be performed before starting the treatment with this medicine. Discontinue the medicine if any abnormality is identified. It is not recommended for use in patients with active and/or severe liver diseases.
Food interactions
Information not available.
Lab interactions
Thyroid function tests
This medicine may alter thyroid function tests. It is advised that you inform the doctor and the laboratory technicians about this medicine before undergoing any laboratory tests.
Urine ketone test
This medicine may lead to a false interpretation of the urine ketone test. It is advised that you inform the doctor and the laboratory technicians about this medicine before undergoing any laboratory tests.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.