INTRODUCTION
NEOMIT 4MG contains Ondansetron which belongs to a group of medicines called anti-emetics, which help to stop feeling or being sick. It is indicated to prevent and treat nausea and vomiting induced by cytotoxic therapy and radiotherapy and post-operative nausea and vomiting. This medicine works by blocking the action of serotonin levels in the brain which causes nausea and vomiting during chemotherapy or any other surgery.
Cytotoxic chemotherapy triggers the release of serotonin from the enterochromaffin cells of the small intestine. The released serotonins stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex. Ondansetron is a selective 5-HT3 receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
Before receiving NEOMIT 4MG, tell your doctor if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. Your doctor will administer the right dose depends on your child’s age and body weight. The common side effects are headache, constipation and dizziness.
USES OF NEOMIT 4MG
- Cancer chemotherapy-induced nausea and vomiting
- Postoperative nausea and/or vomiting
HOW NEOMIT 4MG WORKS
NEOMIT 4MG is a selective 5-HT3-receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
DIRECTIONS FOR USE
NEOMIT 4MG should be only given by a doctor or nurse. Your healthcare provider will administer as intravenous injection (into a vein) or, after dilution, as intravenous infusion.
SIDE EFFECTS OF NEOMIT 4MG
COMMON
- Headache
- Sensation of flushing and warmth
- Constipation
- Pain, redness, burning at injection site
RARE
- Dizziness during rapid intravenous administration
- Skin rash
- Transient visual disturbances (blurred vision)
- Chest pain
- Temporary loss of vision
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and drink plenty of fluids.
Constipation:
Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
WARNING & PRECAUTIONS
PREGNANCY
NEOMIT 4MG is not recommended in the first trimester of pregnancy unless necessary. Consult your doctor for advice.
BREASTFEEDING
NEOMIT 4MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
This medicine has no or negligible effect on the ability to drive or use machines.
LIVER
NEOMIT 4MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Tell if you are allergic (hypersensitive) to Ondansetron.
HEART DISEASE
NEOMIT 4MG should be used with caution in patients suffering from uneven heartbeat or any other active heart diseases. Consult your doctor for advice.
OTHERS
Inform your doctor if you have or had,
- Blockage in your gut or suffer from severe constipation
- Surgery to the adenoids or tonsils
- Problems with the levels of salts in blood like potassium and magnesium
INTERACTIONS
Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,
- Apomorphine (used to treat Parkinson’s Disease)
- Phenytoin, carbamazepine (used to treat epilepsy)
- Rifampicin, erythromycin (an antibiotic)
- Tramadol (used to treat pain)
- Haloperidol, methadone
- Medicines used to treat heart problems such as abnormal heart beats (anti-arrhythmics)
- Fluoxetine, paroxetine, sertraline (used to treat depression)
- Anthracyclines
- Ketoconazole (used to treat fungal infection)
