Duotrol SR 5mg/500mg Tablet (Glibenclamide /Metformin)

Introduction to Duotrol-SR 5mg/500mg Tablet

A combination drug called Duotrol-SR 5mg/500mg Tablet has the two active components glibenclamide and metformin. It is used to assist control blood sugar levels in the treatment of type 2 diabetes. Glibenclamide is a member of the sulfonylurea medicine class, whereas Metformin is a biguanide drug. By promoting insulin secretion and raising insulin sensitivity, this combination has a twofold effect.

How Does Duotrol-SR Work?

1. Glibenclamide: Glibenclamide promotes the secretion of insulin from the pancreas, which lowers blood sugar levels. It works by blocking the potassium channels that are ATP-sensitive in the beta cells of the pancreas, increasing insulin production.
2. Metformin: Metformin increases the sensitivity of muscle and fat cells to insulin while lowering glucose synthesis in the liver. It also aids in reducing the intestinal absorption of glucose. More effective blood sugar regulation results from these actions.

Usage and Dosage

1. Duotrol-SR 5mg/500mg Tablet should only be taken with a legitimate prescription from a medical expert. Observe the recommended dosage and course of treatment.
2. Timing and administration: To improve absorption and lower the chance of stomach discomfort, use Duotrol-SR Tablet with meals. With a glass of water, completely assimilate the tablet. If not directed otherwise by your healthcare practitioner, do not chew or crush the tablet.
3. Individualised Dosage: Depending on your medical condition, how you respond to therapy, and other drugs you are taking, the dosage of Duotrol-SR may change. The best dosage for you will be chosen by your healthcare practitioner.

Precautions and Warnings

1. Duotrol-SR can reduce blood sugar levels if you have hypoglycemia. Regular blood sugar monitoring is crucial, as is being aware of the warning signs and symptoms of hypoglycemia, which include sweating, drowsiness, confusion, and weakness. Follow the advice given to you by your doctor for treating low blood sugar.
2. Avoid using Duotrol-SR Tablet if you are allergic to Glibenclamide, Metformin, or any other sulfonylureas or biguanides. If you suffer symptoms of an allergic response, such as a rash, itching, swelling, or trouble breathing, get emergency medical treatment.
3. Liver and Kidney Function: Let your doctor know if you have any liver or kidney issues. The use and dosage of Duotrol-SR Tablet can be impacted by several situations. The health of the kidneys and liver should be regularly monitored.
4. Drug interactions: Be sure to let your doctor know about all the prescription, over-the-counter, and herbal supplements you are currently taking. Duotrol-SR and specific drugs may interact, reducing the efficacy or raising the possibility of negative side effects.

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Side Effects

Some people may have specific negative effects from taking Duotrol-SR 5mg/500mg Tablet. It is crucial to be aware of these adverse effects even though not everyone encounters them. Typical adverse reactions to Duotrol-SR include:

1. Hypoglycemia: Taking Duotrol-SR might cause low blood sugar, also known as hypoglycemia. Shaking, dizziness, sweating, confusion, and blurred vision are all signs of hypoglycemia. Regular blood sugar checks are crucial, and you should always be prepared to treat low blood sugar episodes with a quick source of glucose, like fruit juice or glucose pills.
2. GI Symptoms: Some people may develop gastrointestinal symptoms as nausea, vomiting, diarrhoea, or abdominal pain. These symptoms are typically transient and minor. These symptoms might be improved by taking Duotrol-SR with food or by changing the dosing schedule.
3. Weight Gain: Duotrol-SR may cause weight gain as a side effect. While using this drug, it’s crucial to maintain a healthy lifestyle, which includes a balanced diet and regular exercise.
4. Rarely, some individuals may encounter skin responses including hives, redness, or itching. It’s crucial to see your doctor for additional testing if you experience any skin complaints.
5. Rarely, the drug Duotrol-SR may result in abnormalities of the liver’s function. Yellowing of the skin or eyes, dark urine, or ongoing stomach pain are all possible symptoms. Seek emergency medical help if you encounter any of these symptoms.

Potential Drug Interactions

All of the medications you are taking, including prescription, over-the-counter, and herbal supplements, should be disclosed to your healthcare physician. Duotrol-SR 5mg/500mg Tablet may interact with other drugs, possibly reducing effectiveness or raising risk of adverse effects. You should be aware of the following typical medication interactions:

1. Beta-Blockers: Taking Duotrol-SR concurrently with beta-blockers like propranolol or metoprolol can disguise the signs of low blood sugar and make it more challenging to diagnose and manage hypoglycemia. When taking both medications, it’s crucial to regularly check your blood sugar levels.
2. Thiazide Diuretics: Thiazide diuretics, such as hydrochlorothiazide, might raise blood sugar levels and lessen Duotrol-SR’s efficiency. Your doctor might need to change the dosage of Duotrol-SR you’re taking or keep a closer eye on your blood sugar levels.
3. ACE Inhibitors and Angiotensin Receptor Blockers (ARBs): These drugs, frequently used to treat high blood pressure, may increase the effects of Duotrol-SR’s blood sugar-lowering properties. It is advised to regularly check blood sugar levels when using these drugs together.
4. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): When used with Duotrol-SR, NSAIDs such ibuprofen or naproxen may raise the chance of developing hypoglycemia. If you use NSAIDs frequently, use caution and keep an eye on your blood sugar levels.
5. Cimetidine: Cimetidine, an acid-reducing medicine, may interact with Duotrol-SR and raise the blood level of Glibenclamide. This may make hypoglycemia more likely. If you take both drugs, your blood sugar levels must be closely monitored.

It’s crucial to remember that this list of drug interactions is not all-inclusive. Before beginning or quitting any new drug, always speak with your healthcare practitioner or chemist for a thorough analysis of your current prescriptions and any possible interactions.

Conclusion

An efficient combination drug for the control of type 2 diabetes is duotrol-SR 5mg/500mg Tablet. It enhances insulin sensitivity while combining the advantages of glibenclamide and metformin to help regulate blood sugar levels. Pay attention to your doctor’s recommendations for dosage, timing, and safety measures. In addition to a healthy diet and regular exercise, regular blood sugar testing can help with diabetes control. Ask your healthcare practitioner for more advice if you notice any side effects or have questions about the medicine. Duotrol-SR can assist you in achieving improved glycemic control and upholding a healthier lifestyle with the appropriate treatment strategy.