Introduction
Saxagliptin and metformin are the two active components that are included in a single dose of the combination drug known as Kombiglyze XR 5mg/1000mg Tablet. It is recommended for the management of diabetic complications associated with type 2 diabetes. This combination drug targets various pathways that are involved in the regulation of glucose, which enables it to help manage blood sugar levels.
How Kombiglyze XR 5mg/1000mg Tablet Works
Saxagliptin is a member of the class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Saxagliptin is used to treat type 2 diabetes. It accomplishes this by blocking the activity of the enzyme DPP-4, which is responsible for deactivating the incretin hormones and so enhancing insulin production while simultaneously decreasing glucagon secretion. Saxagliptin’s ability to inhibit DPP-4 contributes to an increase in insulin production and a decrease in blood glucose levels.
Metformin is a biguanide prescription that works by lowering the amount of glucose that is produced by the liver and enhancing the body’s response to insulin. Metformin is the generic name for the brand-name drug Glucophage. Additionally, it improves the utilisation of glucose by muscular tissues, which in turn results in a reduction in insulin resistance. Metformin has been shown to have favourable benefits on lipid metabolism, and it also has the potential to cause some persons to experience a slight decrease of weight.
Dosage and Administration
It is imperative that you take the Kombiglyze XR 5mg/1000mg Tablet in accordance with the instructions provided by your healthcare professional. It is possible for the dosage to change based on how an individual responds to treatment and their specific demands. In order to reduce the likelihood of stomach upset, it is recommended to only take it once per day, preferably with food. The steady release of the medication over the course of time is made possible by the extended-release formulation, which also offers ongoing control of blood sugar levels.
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Potential Side Effects
Headache, infection of the upper respiratory tract or urinary tract, infection of the urinary tract, diarrhoea, and nausea are some of the possible common adverse effects of the Kombiglyze XR 5mg/1000mg Tablet. These adverse effects are often moderate in nature and short-lived. However, if they continue or start to cause you discomfort, you should make an appointment with your primary care physician.
Rarely, but still possible, serious side effects of Kombiglyze XR 5mg/1000mg Tablet include severe allergic responses, pancreatitis (inflammation of the pancreas), and lactic acidosis (a buildup of lactic acid in the body). These side effects are caused by an accumulation of lactic acid in the body. If you are experiencing symptoms such as severe abdominal pain, prolonged nausea and vomiting, or unusual exhaustion, you should get medical assistance as soon as possible.
Precautions and Warnings
- It is not recommended for people who have type 1 diabetes or diabetic ketoacidosis to take the Kombiglyze XR 5mg/1000mg Tablet.
- Before beginning treatment with Kombiglyze XR, it is imperative that you discuss any pre-existing medical issues, such as kidney or liver illness, heart disease, or any allergies, with your primary care physician.
- Because Metformin may have an effect on the renal function of certain people, it is essential to have your kidney function monitored on a regular basis while taking Kombiglyze XR.
- It is important that you tell your healthcare practitioner about any and all medications you are presently taking because this medication may have an adverse interaction with one or more of the other medications you are taking.
Important Information
- It is not recommended that the Kombiglyze XR 5mg/1000mg Tablet be utilised in the treatment of type 1 diabetes or diabetic ketoacidosis. Persons diagnosed with diabetes mellitus type 2 are the designated target audience for this product.
- The addition of Saxagliptin to Metformin in the formulation of Kombiglyze XR results in the production of complementary mechanisms of action that contribute to the regulation of blood sugar levels.
- While taking Kombiglyze XR, it is essential to keep a healthy lifestyle, including following a well-balanced diet, being physically active on a regular basis, and maintaining a healthy weight. Doing so will help the medication work more effectively.
How to Take Kombiglyze XR 5mg/1000mg Tablet
- Always follow your doctor’s instructions when taking any medication, including the Kombiglyze XR 5mg/1000mg Tablet.
- Take the tablet as directed, along with a full glass of water. Do not chew the tablet, crush it, or break it in any way.
- It is normally recommended to take Kombiglyze XR once daily with a meal in order to reduce the likelihood of experiencing adverse effects on the gastrointestinal tract.
- Because it is an extended-release medicine, Kombiglyze XR ensures that the medication is released in a manner that is both progressive and continuous during the course of the day.
Potential Side Effects and Precautions
- Headache, infection of the upper respiratory tract or urinary tract, infection of the urinary tract, diarrhoea, and nausea are some of the possible common adverse effects of the Kombiglyze XR 5mg/1000mg Tablet. These adverse effects are often moderate in nature and short-lived.
- Seek emergency medical assistance if you develop side effects that are severe or continue for an extended period of time, such as severe abdominal discomfort, weight loss for no apparent reason, or evidence of an allergic reaction.
- Informing your healthcare practitioner about any pre-existing medical issues, such as kidney or liver illness, heart disease, or any allergies, is important before beginning treatment with Kombiglyze XR because these disorders may alter how well the medication works.
- Because Metformin may have an effect on kidney function, it is critical to perform routine checks on this organ, and this is especially true for people who already have kidney disease.
Drug Interactions
There is a possibility that Kombiglyze XR will interact negatively with other drugs, including other diabetic medications, beta-blockers, and diuretics. Your healthcare provider has to be aware of all the medications you are currently taking in order to prevent the possibility of adverse drug reactions.
When taken with metformin, drinking alcohol may bring about an increased likelihood of developing lactic acidosis. When you are using Kombiglyze XR, it is best to limit or completely avoid drinking alcohol.
Conclusion
The combination drug Kombiglyze XR 5mg/1000mg Tablet is an effective treatment for the control of diabetes mellitus type 2. Saxagliptin and Metformin, when combined, are able to target numerous elements of glucose regulation, hence assisting in the regulation of blood sugar levels. When taking this medicine, as with any other, it is critical to adhere to the dosage instructions provided by your healthcare provider and to get in touch with them if you have any questions or concerns about the potential for adverse effects. Monitoring the condition on a regular basis and making changes to one’s lifestyle, such as eating healthily and being active on a daily basis, are also necessary components of an effective diabetes management plan for type 2 patients.
